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Article

Differential expression of Cosmc, T-synthase and mucins in Tn-positive colorectal cancers.

BMC cancer - 16 Aug 2018

Sun Xiaodong, Ju Tongzhong, Cummings Richard D

Abstract excerpt

BACKGROUND: The Tn neoantigen (GalNAcα1-O-Ser/Thr) is an O-glycan expressed in various types of human cancers. Studies in several Tn-expressing cancer cell lines and pancreatic tumors have identified loss of Cosmc expression caused by either mutations or promoter hypermethylation. In this study, we explored the mechanism(s) for Tn expression in human colorectal cancers (CRC). METHODS: Tn-expressing cell...

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Share to Antigens, Tumor-Associated, Carbohydrate
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 30115016
DOI: 10.1186/s12885-018-4708-8
PMCID: PMC6097208

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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