Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human Tumor Antigens Tn and Sialyl Tn Arise from Mutations in <i>Cosmc</i>

13 Mar 2008

Abstract excerpt

Neoplastic lesions typically express specific carbohydrate antigens on glycolipids, mucins, and other glycoproteins. Such antigens are often under epigenetic control and are subject to reversion and loss upon therapeutic selective pressure. We report here that two of the most common tumor-associated carbohydrate antigens, Tn and sialyl Tn (STn), result from somatic mutations in the gene Cosmc that encodes a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Galectins and Cancer Biology
Share to Glycosylation and Glycoproteins Research
Share to Monoclonal and Polyclonal Antibodies Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 18339842
DOI: 10.1158/0008-5472.can-07-2345

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human Tumor Antigens Tn and Sialyl Tn Arise from Mutations in <i>Cosmc</i>PMID 18339842Read ↗

Differential expression of Cosmc, T-synthase and mucins in Tn-positive colorectal cancers.Semantic proximity Read ↗

Aberrant Cosmc genes result in Tn antigen expression in human colorectal carcinoma cell line HT-29.Semantic proximity Read ↗

Cosmc is an essential chaperone for correct protein O-glycosylation.Semantic proximity Read ↗

A mutant chaperone converts a wild-type protein into a tumor-specific antigen.Semantic proximity Read ↗

The Role of Sialyl-Tn in CancerSemantic proximity Read ↗

A unique molecular chaperone Cosmc required for activity of the mammalian core 1 beta 3-galactosyltransferase.Semantic proximity Read ↗

The Cancer-Associated Antigens Sialyl Lewisa/x and Sda: Two Opposite Faces of Terminal GlycosylationSemantic proximity Read ↗

New mutations in C1GALT1C1 in individuals with Tn positive phenotype.Semantic proximity Read ↗

Functional assays for the molecular chaperone cosmc.Semantic proximity Read ↗

Protein glycosylation: chaperone mutation in Tn syndrome.Semantic proximity Read ↗

Cosmc transfection decreases malignant behavior of Tn+ cells and enhances sensitivity to apoptosis when induced by Apo2L/TRAIL via alteration of O-glycan structure.Semantic proximity Read ↗

Germline C1GALT1C1 Mutation Causes a Multisystemic Chaperonopathy with Global Deficiency of Core 1-derived O-GlycosylationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.