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Article

Cosmc is an essential chaperone for correct protein O-glycosylation.

Proceedings of the National Academy of Sciences of the United States of America - 18 May 2010

Wang Yingchun, Ju Tongzhong, Ding Xiaokun, Xia Baoyun, Wang Wenyi, Xia Lijun, He Miao, Cummings Richard D

Abstract excerpt

Cosmc is a molecular chaperone thought to be required for expression of active T-synthase, the only enzyme that galactosylates the Tn antigen (GalNAcalpha1-Ser/Thr-R) to form core 1 Galbeta1-3GalNAcalpha1-Ser/Thr (T antigen) during mucin type O-glycan biosynthesis. Here we show that ablation of the X-linked Cosmc gene in mice causes embryonic lethality and Tn antigen expression. Loss of Cosmc is associated with...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 20439703
DOI: 10.1073/pnas.0914004107
PMCID: PMC2889116

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Cosmc is an essential chaperone for correct protein O-glycosylation.PMID 20439703Read ↗

Functional assays for the molecular chaperone cosmc.Semantic proximity Read ↗

A unique molecular chaperone Cosmc required for activity of the mammalian core 1 beta 3-galactosyltransferase.Semantic proximity Read ↗

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Human Tumor Antigens Tn and Sialyl Tn Arise from Mutations in <i>Cosmc</i>Semantic proximity Read ↗

Protein glycosylation: chaperone mutation in Tn syndrome.Semantic proximity Read ↗

Germline C1GALT1C1 mutation causes a multisystem chaperonopathy.Semantic proximity Read ↗

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