Clinical utility of comprehensive genomic profiling test for colorectal cancer: a single institution prospective observational study.

doi:10.1007/s00432-025-06295-7

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Article

Clinical utility of comprehensive genomic profiling test for colorectal cancer: a single institution prospective observational study.

Journal of cancer research and clinical oncology - 10 Sept 2025

Tanabe Hiroki, Ando Katsuyoshi, Takahashi Keitaro, Kamanaka Tomomi, Yuzawa Sayaka, Kikuchi Junko, Ohhara Yoshihito, Ariga Shin, Shonaka Tatsuya, Tani Chikayoshi, Otake Shin, Sasaki Takaaki, Takahashi Kenji, Ueno Nobuhiro, Moriichi Kentaro, Tanino Mishie, Kinoshita Ichiro, Mizukami Yusuke, Fujiya Mikihiro

Abstract excerpt

PURPOSE: Next-generation sequencing (NGS) has revolutionized cancer treatment by enabling comprehensive cancer genomic profiling (CGP) to guide genotype-directed therapies. While several prospective trials have demonstrated varying outcomes with CGP in patients with advanced solid tumors, its clinical utility in colorectal cancer (CRC) remains to be evaluated. METHODS: We conducted a prospective observational...

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Topics

Humans
Colorectal Neoplasms
Aged
Male
Female

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Prospective Studies

Middle Aged

High-Throughput Nucleotide Sequencing

Aged, 80 and over

Mutation

Biomarkers, Tumor

Adult

Genomics

Prognosis

Source

Open in PubMed Open full text

Identifiers

PMID: 40931253
DOI: 10.1007/s00432-025-06295-7
PMCID: PMC12423004

Genes

TP53
SMAD4
APC
BRAF
ERBB2
KRAS
NF1
PTEN

Variants

Provenance

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