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Article

C. elegans expressing D76N β2-microglobulin: a model for in vivo screening of drug candidates targeting amyloidosis.

Scientific reports - 27 Dec 2019

Faravelli Giulia, Raimondi Sara, Marchese Loredana, Partridge Frederick A, Soria Cristina, Mangione P Patrizia, Canetti Diana, Perni Michele, Aprile Francesco A, Zorzoli Irene, Di Schiavi Elia, Lomas David A, Bellotti Vittorio, Sattelle David B, Giorgetti Sofia

Abstract excerpt

The availability of a genetic model organism with which to study key molecular events underlying amyloidogenesis is crucial for elucidating the mechanism of the disease and the exploration of new therapeutic avenues. The natural human variant of β2-microglobulin (D76N β2-m) is associated with a fatal familial form of systemic amyloidosis. Hitherto, no animal model has been available for studying in vivo the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31882874
DOI: 10.1038/s41598-019-56498-5
PMCID: PMC6934621

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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