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Article

Sirtuin 1 enzymatic activity is required for cartilage homeostasis in vivo in a mouse model

2 Nov 2012

Abstract excerpt

OBJECTIVE: We and others previously demonstrated that sirtuin 1 (SIRT-1) regulates apoptosis and cartilage-specific gene expression in human chondrocytes and mouse models. This study was undertaken to determine if SIRT-1 enzymatic activity plays a protective role in cartilage homeostasis in vivo, by investigating mice with SIRT-1 mutations to characterize their cartilage. METHODS: Articular cartilage was...

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PMID: 23124828
DOI: 10.1002/art.37750

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