Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Sirt1-deficient mice exhibit an altered cartilage phenotype.

Joint bone spine - 1 Dec 2013

Gabay Odile, Zaal Kristien J, Sanchez Christelle, Dvir-Ginzberg Mona, Gagarina Viktoria, Song Yingjie, He Xiao Hong, McBurney Michael W

Abstract excerpt

OBJECTIVE: We previously demonstrated that Sirt1 regulates apoptosis in cartilage in vitro. Here we attempt to examine in vivo cartilage homeostasis, using Sirt1 total body knockout (KO) mice. METHOD: Articular cartilage was harvested from hind paws of 1-week and 3-week-old mice carrying wild typ...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apoptosis
Share to Cartilage, Articular
Share to Chondrocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Disease Models, Animal

Share to Homeostasis

Share to Mice, Knockout

Share to Osteoarthritis

Source

Open in PubMed Open full text

Identifiers

PMID: 23587642
DOI: 10.1016/j.jbspin.2013.01.001
PMCID: PMC4288855

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23587642-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sirt1-deficient mice exhibit an altered cartilage phenotype.PMID 23587642Read ↗

Sirtuin 1 enzymatic activity is required for cartilage homeostasis in vivo in a mouse modelSemantic proximity Read ↗

Potential involvement of SIRT1 in the pathogenesis of osteoarthritis through the modulation of chondrocyte gene expressionsSemantic proximity Read ↗

Knee Osteoarthritis Progression Is Delayed in Silent Information Regulator 2 Ortholog 1 Knock-in Mice.Semantic proximity Read ↗

SIRT1 regulation of apoptosis of human chondrocytesSemantic proximity Read ↗

Knockout of longevity gene Sirt1 in zebrafish leads to oxidative injury, chronic inflammation, and reduced life spanSemantic proximity Read ↗

sirt1-null mice develop an autoimmune-like conditionSemantic proximity Read ↗

Resveratrol protects against IL-1β-induced chondrocyte damage via the SIRT1/FOXO1 signalling pathwaySemantic proximity Read ↗

SIRT1 Inhibits the Catabolic Effect of IL-1βThrough TLR2/SIRT1/NF-κB Pathway in HumanDegenerative Nucleus Pulposus CellsSemantic proximity Read ↗

Sirt1 protects against intervertebral disc degeneration induced by 1,25-dihydroxyvitamin D insufficiency in mice by inhibiting the NF-κB inflammatory pathwaySemantic proximity Read ↗

Disruption of Igfbp1 fails to rescue the phenotype of Sirt1-/- mice.Semantic proximity Read ↗

Insulin/IGF-1R, SIRT1, and FOXOs Pathways—An Intriguing Interaction Platform for Bone and OsteosarcomaSemantic proximity Read ↗

IGF1 drives Wnt-induced joint damage and is a potential therapeutic target for osteoarthritisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.