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Article

Novel genomic alteration in superficial esophageal squamous cell neoplasms in non-smoker non-drinker females.

Scientific reports - 11 Oct 2021

Onozato Yusuke, Sasaki Yu, Abe Yasuhiko, Sato Hidenori, Yagi Makoto, Mizumoto Naoko, Kon Takashi, Sakai Takayuki, Ito Minami, Umehara Matsuki, Koseki Ayumi, Ueno Yoshiyuki

Abstract excerpt

Alcohol consumption and smoking pose a significant risk for esophageal squamous cell neoplasia (ESCN) development in males; however, ESCN is often diagnosed in non-drinking and non-smoking females. The mechanisms underlying these differences remain elusive, and understanding them can potentially identify novel pathways involved in ESCN development. We performed short-read sequencing to identify somatic variants...

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Identifiers

PMID: 34635759
DOI: 10.1038/s41598-021-99790-z
PMCID: PMC8505482

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