Article
A CRISPR/Cas9 strategy for the generation of a FLNC knockout hESC line (WAe009-A-70) to model dilated cardiomyopathy and arrhythmogenic right ventricular cardiomyopathy.
Stem cell research - 1 Oct 2021
Qin Zhiping, Sun Liqiang, Sun Xue, Su Hang, Gao Xinxuan
Abstract excerpt
The FLNC gene encodes the sarcomeric protein filamin C which plays a central role in cardiomyocytes. Truncating FLNC mutations (stop or frameshift etc.) also cause dilated cardiomyopathy (DCM) and arrhythmogenic right ventricular cardiomyopathy (ARVC). To further understand the exact role of FLNC in DCM, we have generated a human FLNC knockout cell line from the original embryonic stem cell line H9 by CRISPR/Cas9...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.