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Article

Generation of three TTN knock-out human induced pluripotent stem cell lines using CRISPR/Cas9 system.

Stem cell research - 1 Oct 2022

Kang Ji-Young, Mun Dasom, Chun Yumin, Park Da-Seul, Kim Hyoeun, Yun Nuri, Lee Seung-Hyun, Joung Boyoung

Abstract excerpt

TTN mutations are the common genetic cause for various types of cardiomyopathies (e.g., dilated cardiomyopathy, hypertrophic cardiomyopathy, restrictive cardiomyopathy, and arrhythmogenic right ventricular cardiomyopathy) and skeletal myopathies. Here, we generated three TTN knock-out human induced pluripotent stem cell (iPSC) lines using CRISPR/Cas9 system. These cell lines, which exhibit normal karyotype,...

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Identifiers

PMID: 36037555
DOI: 10.1016/j.scr.2022.102901

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