Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Generation of a heterozygous TPM1-E192K knock-in human induced pluripotent stem cell line using CRISPR/Cas9 system.

Stem cell research - 1 Aug 2022

Kang Ji-Young, Mun Dasom, Chun Yumin, Kim Hyoeun, Yun Nuri, Lee Seung-Hyun, Joung Boyoung

Abstract excerpt

E192K missense mutation of TPM1 has been found in different types of cardiomyopathies (e.g., hypertrophic cardiomyopathy, dilated cardiomyopathy, and left ventricular non-compaction), leading to systolic dysfunction, diastolic dysfunction, and/or tachyarrhythmias. Here, we generated a heterozygous TPM1-E192K knock-in human induced pluripotent stem cell (iPSC) line using CRISPR/Cas9-based genome editing system....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cardiomyopathies
Share to CRISPR-Cas Systems

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Editing

Share to Heterozygote

Share to Induced Pluripotent Stem Cells

Share to Mutation

Share to Tropomyosin

Source

Identifiers

PMID: 35917600
DOI: 10.1016/j.scr.2022.102878

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Generation of a heterozygous TPM1-E192K knock-in human induced pluripotent stem cell line using CRISPR/Cas9 system.PMID 35917600Read ↗

Generation of three TTN knock-out human induced pluripotent stem cell lines using CRISPR/Cas9 system.Semantic proximity Read ↗

Generation of CRISPR/Cas9 edited human induced pluripotent stem cell line carrying the heterozygous p.H695VfsX5 frameshift mutation in the exon 10 of the PKP2 gene.Semantic proximity Read ↗

Generation of human induced pluripotent stem cell line LUMCi027-A and its isogenic gene-corrected line from a patient affected by arrhythmogenic cardiomyopathy and carrying the c.2013delC PKP2 mutation.Semantic proximity Read ↗

Modeling of dilated cardiomyopathy by establishment of isogenic human iPSC lines carrying phospholamban C25T (R9C) mutation (UPITTi002-A-1) using CRISPR/Cas9 editing.Semantic proximity Read ↗

Genomic Engineering of Induced Pluripotent Stem Cell-Derived Cardiomyocytes.Semantic proximity Read ↗

Human Induced Pluripotent Stem-Cell-Derived Cardiomyocytes as Models for Genetic CardiomyopathiesSemantic proximity Read ↗

Induced pluripotent stem cells in the inherited cardiomyopathies: From disease mechanisms to novel therapies.Semantic proximity Read ↗

Untangling the Biology of Genetic Cardiomyopathies with Pluripotent Stem Cell Disease Models.Semantic proximity Read ↗

Generation of human induced pluripotent stem cell line carrying SCN5AC2204>T Brugada mutation (MUSli009-A-1) introduced by CRISPR/Cas9-mediated genome editing.Semantic proximity Read ↗

A CRISPR/Cas9 strategy for the generation of a FLNC knockout hESC line (WAe009-A-70) to model dilated cardiomyopathy and arrhythmogenic right ventricular cardiomyopathy.Semantic proximity Read ↗

Generation of iPSC line from MYH7 R403L mutation carrier with severe hypertrophic cardiomyopathy and isogenic CRISPR/Cas9 corrected control.Semantic proximity Read ↗

A heterozygous MYBPC3 (c. 772+1G > A) mutant human induced pluripotent stem cell line (ZZUNEUi025-A) generated from a male patient with hypertrophic cardiomyopathy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.