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Article

Generation of a laminopathies-specific iPSC line EHTJUi005-A-3 with homozygous knockout of the LMNA gene by CRISPR/Cas9 technology.

Stem cell research - 1 Oct 2021

Lu Ji-Zhen, Qiao Zhi-Bin, Zhang Lu, Cao Hong-Xia, Bai Zhi-Hui, Qi Yi-Yao, Zhu Han-Yu, Chen Ya-Qi, Zhang Shou-Mei, Yan Xiu-Hua, Bao Yan, Jia Wen-Wen, Liu Zhong-Min

Abstract excerpt

LAMIN A/C, encoded by the LMNA gene, supports the normal structure of the cell nucleus and regulates the connection between the nucleus and the cytoskeleton as a component of the nucleus envelope. The loss of expression and function of the LMNA gene would lead to the occurrence of congenital muscular dystrophy and Emery-Dreifuss muscular dystrophy which are collectively named as laminopathies. Here, we report a...

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Identifiers

PMID: 34507144
DOI: 10.1016/j.scr.2021.102530

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Generation of a laminopathies-specific iPSC line EHTJUi005-A-3 with homozygous knockout of the LMNA gene by CRISPR/Cas9 technology.PMID 34507144Read ↗

Modeling Skeletal Muscle Laminopathies Using Human Induced Pluripotent Stem Cells Carrying Pathogenic LMNA MutationsSemantic proximity Read ↗

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Advanced human iPSC-based modelling of <i>LMNA</i> -related congenital muscular dystrophy enables development of targeted genetic therapies for muscle laminopathiesSemantic proximity Read ↗

Establishment of a novel human iPSC line (YCMi003-A) from a patient with dilated cardiomyopathy carrying genetic variant LMNA p.Asp364His.Semantic proximity Read ↗

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Generation of an isogenic gene-corrected iPSC line (PUMCHi001-A-1) from a familial partial lipodystrophy type 2 (FPLD2) patient with a heterozygous R349W mutation in the LMNA gene.Semantic proximity Read ↗

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