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Article

Generation of a FLNA knockout hESC line (WAe009-A-P) to model cardiac valvular dysplasia using CRISPR/Cas9.

Stem cell research - 1 Sept 2023

Lu Fengyuan, Gao Yifeng, Li En

Abstract excerpt

The FLNA gene encodes the cytoskeletal protein filamin A which plays a key role in the structure and function of the cardiac valves. Truncating FLNA mutations are associated with cardiac valvular dysplasia. To further understand the exact role of FLNA in this disease, we have generated a human FLNA knockout cell line from H9 using CRISPR/Cas9 technology in this study. This cell line WAe009-A-P has a 2 bp deletion...

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Identifiers

PMID: 37429070
DOI: 10.1016/j.scr.2023.103162

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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