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Article

Generation of a heterozygous FLNC mutation-carrying human iPSC line, USFi002-A, for modeling dilated cardiomyopathy.

Stem cell research - 1 May 2021

Argenziano Mariana A, Burgos Angulo Mariana, Najari Beidokhti Maliheh, Yang Jiajia, Bertalovitz Alexander C, McDonald Thomas V

Abstract excerpt

Dilated Cardiomyopathy (DCM) is one of the main causes of sudden cardiac death and heart failure and is the leading indication for cardiac transplantation worldwide. Mutations in different genes including TTN, MYH7, and LMNA, have been linked to the development of DCM. Here, we generated a human induced pluripotent stem cell (IPSC) line from a DCM patient with a familial history that carries a frameshift mutation...

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Identifiers

PMID: 34088019
DOI: 10.1016/j.scr.2021.102394

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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Research trail→

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Generation of a heterozygous FLNC mutation-carrying human iPSC line, USFi002-A, for modeling dilated cardiomyopathy.PMID 34088019Read ↗

Generation of two induced pluripotent stem cell lines from dilated cardiomyopathy patients carrying heterozygous FLNC mutations.Semantic proximity Read ↗

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