Article
Longitudinal stability of molecular alterations and drug response profiles in tumor spheroid cell lines enables reproducible analyses.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - 1 Dec 2021
Nickel A C, Picard D, Qin N, Wolter M, Kaulich K, Hewera M, Pauck D, Marquardt V, Torga G, Muhammad S, Zhang W, Schnell O, Steiger H-J, Hänggi D, Fritsche E, Her N-G, Nam D-H, Carro M S, Remke M, Reifenberger G, Kahlert U D
Abstract excerpt
The utility of patient-derived tumor cell lines as experimental models for glioblastoma has been challenged by limited representation of the in vivo tumor biology and low clinical translatability. Here, we report on longitudinal epigenetic and transcriptional profiling of seven glioblastoma spheroid cell line models cultured over an extended period. Molecular profiles were associated with drug response data...
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