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Article

Neuroinflammatory and behavioural changes in the Atp7B mutant mouse model of Wilson's disease.

Journal of neurochemistry - 1 Jul 2011

Terwel Dick, Löschmann Yi-Na, Schmidt Hartmut H-J, Schöler Hans R, Cantz Tobias, Heneka Michael T

Abstract excerpt

Wilson's disease (WD) is caused by mutations in the copper transporting ATPase 7B (Atp7b). Patients present with liver pathology or behavioural disturbances. Studies on rodent models for WD so far mainly focussed on liver, not brain. The effect of knockout of atp7b on sensori-motor and cognitive behaviour, as well as neuronal number, inflammatory markers, copper and synaptic proteins in brain were studied in...

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Identifiers

PMID: 21517843
DOI: 10.1111/j.1471-4159.2011.07278.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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