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Article

APOBEC family mutational signatures are associated with poor prognosis translocations in multiple myeloma.

Nature communications - 23 Apr 2015

Walker Brian A, Wardell Christopher P, Murison Alex, Boyle Eileen M, Begum Dil B, Dahir Nasrin M, Proszek Paula Z, Melchor Lorenzo, Pawlyn Charlotte, Kaiser Martin F, Johnson David C, Qiang Ya-Wei, Jones John R, Cairns David A, Gregory Walter M, Owen Roger G, Cook Gordon, Drayson Mark T, Jackson Graham H, Davies Faith E, Morgan Gareth J

Abstract excerpt

We have sequenced 463 presenting cases of myeloma entered into the UK Myeloma XI study using whole exome sequencing. Here we identify mutations induced as a consequence of misdirected AID in the partner oncogenes of IGH translocations, which are activating and associated with impaired clinical ou...

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Topics

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Share to Cytidine Deaminase
Share to Gene Expression Profiling

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to MafB Transcription Factor

Share to Minor Histocompatibility Antigens

Share to Multiple Myeloma

Share to Proto-Oncogene Proteins c-myc

Share to Translocation, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 25904160
DOI: 10.1038/ncomms7997
PMCID: PMC4568299

Genes

MAF
MAFB
APOBEC4
IGH
MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25904160-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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