Article
N-acetylcysteine (NAC), an anti-oxidant, does not improve bone mechanical properties in a rat model of progressive chronic kidney disease-mineral bone disorder.
PloS one - 1 Jan 2020
Allen Matthew R, Wallace Joseph, McNerney Erin, Nyman Jeffry, Avin Keith, Chen Neal, Moe Sharon
Abstract excerpt
Individuals with chronic kidney disease have elevated levels of oxidative stress and are at a significantly higher risk of skeletal fracture. Advanced glycation end products (AGEs), which accumulate in bone and compromise mechanical properties, are known to be driven in part by oxidative stress. The goal of this study was to study effects of N-acetylcysteine (NAC) on reducing oxidative stress and improving...
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