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Sirt1 promotes tissue regeneration in zebrafish through regulating the mitochondrial unfolded protein response

11 Sept 2021

Abstract excerpt

The mitochondrial unfolded protein response (UPR mt ) is an organellar stress signaling pathway that functions to detect and restore disruption of mitochondrial proteostasis. The UPR mt is involved in a wide range of physiological and disease conditions, including aging, stem cell maintenance, innate immunity, neurodegeneration, and cancer. Here we report that the UPR mt is integral to zebrafish fin regeneration....

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PMID: 34622167
DOI: 10.1016/j.isci.2021.103118

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