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Article

Temporal evolution of master regulator Crp identifies pyrimidines as catabolite modulator factors.

Nature communications - 7 Oct 2021

Lauritsen Ida, Frendorf Pernille Ott, Capucci Silvia, Heyde Sophia A H, Blomquist Sarah D, Wendel Sofie, Fischer Emil C, Sekowska Agnieszka, Danchin Antoine, Nørholm Morten H H

Abstract excerpt

The evolution of microorganisms often involves changes of unclear relevance, such as transient phenotypes and sequential development of multiple adaptive mutations in hotspot genes. Previously, we showed that ageing colonies of an E. coli mutant unable to produce cAMP when grown on maltose, accumulated mutations in the crp gene (encoding a global transcription factor) and in genes involved in pyrimidine...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34620864
DOI: 10.1038/s41467-021-26098-x
PMCID: PMC8497467

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