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Article

Generation of mutation hotspots in ageing bacterial colonies.

Scientific reports - 5 Dec 2016

Sekowska Agnieszka, Wendel Sofie, Fischer Emil C, Nørholm Morten H H, Danchin Antoine

Abstract excerpt

How do ageing bacterial colonies generate adaptive mutants? Over a period of two months, we isolated on ageing colonies outgrowing mutants able to use a new carbon source, and sequenced their genomes. This allowed us to uncover exquisite details on the molecular mechanism behind their adaptation: most mutations were located in just a few hotspots in the genome, and over time, mutations increasingly were...

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Identifiers

PMID: 28442761
DOI: 10.1038/s41598-016-0005-4
PMCID: PMC5431349

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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