Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Synthesis, microbiological evaluation and structure activity relationship analysis of linezolid analogues with different C5-acylamino substituents

8 Sept 2021

Abstract excerpt

Antimicrobial resistance and lack of new antibiotics to treat multidrug-resistant (MDR) bacteria is a significant public health problem. There is a discovery void and the pipeline of new classes of antibiotics in clinical development is almost empty. Therefore, it is important to understand the structure activity relationships (SAR) of current chemical classes as that can help the drug discovery community in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antimicrobial Resistance in Staphylococcus
Share to Microbial Natural Products and Biosynthesis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34619406
DOI: 10.1016/j.bmc.2021.116397

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Synthesis, microbiological evaluation and structure activity relationship analysis of linezolid analogues with different C5-acylamino substituentsPMID 34619406Read ↗

Linezolid update: stable in vitro activity following more than a decade of clinical use and summary of associated resistance mechanisms.Semantic proximity Read ↗

Linezolid: a review of its properties, function, and use in critical care.Semantic proximity Read ↗

Rχ-01, a New Family of Oxazolidinones That Overcome Ribosome-Based Linezolid ResistanceSemantic proximity Read ↗

Investigation of recent advancement in the pharmacological potential of C-3 substituted coumarin derivatives against S. aureusSemantic proximity Read ↗

Structure–Uptake Relationship Studies of Oxazolidinones in Gram-Negative ESKAPE PathogensSemantic proximity Read ↗

Oxazolidinones: activity, mode of action, and mechanism of resistance.Semantic proximity Read ↗

Structure-Uptake Relationship Studies of Oxazolidinones in Gram-negative ESKAPE PathogensSemantic proximity Read ↗

Structure-activity relationships of diverse oxazolidinones for linezolid-resistant Staphylococcus aureus strains possessing the cfr methyltransferase gene or ribosomal mutations.Semantic proximity Read ↗

Zyvox® Annual Appraisal of Potency and Spectrum Program Results for 2006: an activity and spectrum analysis of linezolid using clinical isolates from 16 countriesSemantic proximity Read ↗

The oxazolidinones: past, present, and future.Semantic proximity Read ↗

Computer aided drug design to generate a new antibiotic familySemantic proximity Read ↗

Novel Tetrazole-Based Antimicrobial Agents Targeting Clinical Bacteria Strains: Exploring the Inhibition of Staphylococcus aureus DNA Topoisomerase IV and GyraseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.