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Article

The oxazolidinones: past, present, and future.

Annals of the New York Academy of Sciences - 1 Dec 2011

Shaw Karen Joy, Barbachyn Michael R

Abstract excerpt

The success of linezolid stimulated significant efforts to discover new agents in the oxazolidinone class. Over a dozen oxazolidinones have reached the clinic, but many were discontinued due to lack of differentiated potency, inadequate pharmacokinetics, and safety risks that included myelosuppression. Four oxazolidinones are currently undergoing clinical evaluation. The Trius Therapeutics compound tedizolid...

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PMID: 22191526
DOI: 10.1111/j.1749-6632.2011.06330.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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