Article
Structure-activity relationships of diverse oxazolidinones for linezolid-resistant Staphylococcus aureus strains possessing the cfr methyltransferase gene or ribosomal mutations.
Antimicrobial agents and chemotherapy - 1 Dec 2010
Locke Jeffrey B, Finn John, Hilgers Mark, Morales Gracia, Rahawi Shahad, G C Kedar, Picazo Juan José, Im Weonbin, Shaw Karen Joy, Stein Jeffrey L
Abstract excerpt
Staphylococcal resistance to linezolid (LZD) is mediated through ribosomal mutations (23S rRNA or ribosomal proteins L3 and L4) or through methylation of 23S rRNA by the horizontally transferred Cfr methyltransferase. To investigate the structural basis for oxazolidinone activity against LZD-resi...
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