Article
Structural and Functional Impact of Damaging Nonsynonymous Single Nucleotide Polymorphisms (nsSNPs) on Human VPS35 Protein Using Computational Approaches.
IEEE/ACM transactions on computational biology and bioinformatics - 1 Jan 2000
Jawad Ul Hasnain Mirza, Amin Farhat, Ghani Aisha, Ahmad Sibtain, Rahman Ziaur, Aslam Tahera, Pervez Muhammad Tariq
Abstract excerpt
Parkinson's disease is the second most common progressive neurodegenerative movement disorder. Mutations in retromer complex subunit and VPS35 represent the second most common cause of late-onset familial Parkinson's disease. The mutation in VPS35 can disrupt the normal protein functions resulting in Parkinson's disease. The aim of this study was the identification of deleterious missense Single Nucleotide...
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