Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic variability of the retromer cargo recognition complex in parkinsonism.

Movement disorders : official journal of the Movement Disorder Society - 1 Apr 2015

Gustavsson Emil K, Guella Ilaria, Trinh Joanne, Szu-Tu Chelsea, Rajput Alex, Rajput Ali H, Steele John C, McKeown Martin, Jeon Beom S, Aasly Jan O, Farrer Matthew J

Abstract excerpt

BACKGROUND: A pathogenic mutation (VPS35 p.D620N) within the retromer complex has been shown to segregate with late-onset Parkinson's disease (PD). Several studies have subsequently detected the mutation in patients with PD and not in controls. METHODS: Mutation screening of the coding regions of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Aged, 80 and over
Share to DNA Mutational Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Variation

Share to International Cooperation

Share to Parkinsonian Disorders

Share to Vesicular Transport Proteins

Share to Young Adult

Source

Identifiers

PMID: 25475142
DOI: 10.1002/mds.26104

Genes

VPS35
VPS29

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25475142-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic variability of the retromer cargo recognition complex in parkinsonism.PMID 25475142Read ↗

Genetic variation of the retromer subunits VPS26A/B-VPS29 in Parkinson's disease.Semantic proximity Read ↗

A mutation in VPS35, encoding a subunit of the retromer complex, causes late-onset Parkinson disease.Semantic proximity Read ↗

VPS35 mutations in Parkinson disease.Semantic proximity Read ↗

VPS35, the Retromer Complex and Parkinson's Disease.Semantic proximity Read ↗

An update on cellular and molecular determinants of Parkinson's disease with emphasis on the role of the retromer complex.Semantic proximity Read ↗

Mutations in VPS26A are not a frequent cause of Parkinson's disease.Semantic proximity Read ↗

VPS35 and retromer dysfunction in Parkinson's disease.Semantic proximity Read ↗

A multi-centre clinico-genetic analysis of the VPS35 gene in Parkinson disease indicates reduced penetrance for disease-associated variants.Semantic proximity Read ↗

Identification of VPS35 mutations replicated in French families with Parkinson disease.Semantic proximity Read ↗

Atypical parkinsonism-associated retromer mutant alters endosomal sorting of specific cargo proteins.Semantic proximity Read ↗

VPS35, the core component of the retromer complex, and Parkinson's diseaseSemantic proximity Read ↗

Structural and Functional Impact of Damaging Nonsynonymous Single Nucleotide Polymorphisms (nsSNPs) on Human VPS35 Protein Using Computational Approaches.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.