Article

Effects of the Pathological E200K Mutation on Human Prion Protein: A Computational screening and Molecular Dynamic approach

2022-01-06

Abstract excerpt

The Human Prion protein gene ( PRNP ) is mapped to short arm of chromosome 20 (20pter-12). Prion disease is associated with mutations in the Prion Protein encoding gene sequence. The mutations that occur in the prion protein could be divided into two types based on their influence on pathogenic potential: 1. Mutations that cause disease. 2. Disease-resistance mutations. Earlier studies found that the mutation G127...

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Literature Corpus work: 46db6941-4b88-5e1e-8e06-753d7715dad3
DOI: 10.21203/rs.3.rs-1202156/v1

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