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Article

Amyotrophic Lateral Sclerosis Type 20 - In Silico Analysis and Molecular Dynamics Simulation of hnRNPA1.

PloS one - 1 Jan 2016

Krebs Bruna Baumgarten, De Mesquita Joelma Freire

Abstract excerpt

Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease that affects the upper and lower motor neurons. 5-10% of cases are genetically inherited, including ALS type 20, which is caused by mutations in the hnRNPA1 gene. The goals of this work are to analyze the effects of non-synonymous single nucleotide polymorphisms (nsSNPs) on hnRNPA1 protein function, to model the complete tridimensional...

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PMID: 27414033
DOI: 10.1371/journal.pone.0158939
PMCID: PMC4945010

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