Article
The BRCA1/BARD1 ubiquitin ligase and its substrates.
The Biochemical journal - 30 Sept 2021
Witus Samuel R, Stewart Mikaela D, Klevit Rachel E
Abstract excerpt
Mutations in breast cancer type 1 susceptibility protein (BRCA1) and its heterodimeric binding partner BARD1 confer a high risk for the development of breast and ovarian cancers. The sole enzymatic function of the BRCA1/BARD1 complex is as a RING-type E3 ubiquitin (Ub) ligase, leading to the deposition of Ub signals onto a variety of substrate proteins. Distinct types of Ub signals deposited by BRCA1/BARD1 (i.e....
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