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Article

NMR and EPR-DEER Structure of a Dimeric Guanylate Cyclase Activator Protein-5 from Zebrafish Photoreceptors.

Biochemistry - 19 Oct 2021

Cudia Diana, Roseman Graham P, Assafa Tufa E, Shahu Manisha Kumari, Scholten Alexander, Menke-Sell Sarah-Karina, Yamada Hiroaki, Koch Karl-W, Milhauser Glenn, Ames James B

Abstract excerpt

Retinal guanylate cyclases (RetGCs) are regulated by a family of guanylate cyclase-activating proteins (called GCAP1-7). GCAPs form dimers that bind to Ca2+ and confer Ca2+ sensitive activation of RetGC during visual phototransduction. The GCAP5 homologue from zebrafish contains two nonconserved cysteine residues (Cys15 and Cys17) that bind to ferrous ion, which stabilizes GCAP5 dimerization and diminishes its...

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Identifiers

PMID: 34609135
DOI: 10.1021/acs.biochem.1c00612
PMCID: PMC8944188

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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