Article
Structural Characterization of Ferrous Ion Binding to Retinal Guanylate Cyclase Activator Protein 5 from Zebrafish Photoreceptors.
Biochemistry - 26 Dec 2017
Lim Sunghyuk, Scholten Alexander, Manchala Grace, Cudia Diana, Zlomke-Sell Sarah-Karina, Koch Karl-W, Ames James B
Abstract excerpt
Sensory guanylate cyclases (zGCs) in zebrafish photoreceptors are regulated by a family of guanylate cyclase activator proteins (called GCAP1-7). GCAP5 contains two nonconserved cysteine residues (Cys15 and Cys17) that could in principle bind to biologically active transition state metal ions (Zn2+ and Fe2+). Here, we present nuclear magnetic resonance (NMR) and isothermal titration calorimetry (ITC) binding...
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