Article

Supramolecular complexes of GCAP1: towards the development of effective biologics for inherited retinal dystrophies

2024-03-11

Abstract excerpt

Guanylate Cyclase Activating Protein 1 (GCAP1) is a neuronal Ca 2+ -sensor protein expressed in photoreceptors where it regulates the enzymatic activity of retinal Guanylate Cyclase 1 (GC1) in a Ca 2+ -dependent manner. Recently, over 20 missense mutations in GUCA1A (encoding for GCAP1) have been associated with inherited autosomal dominant retinal diseases, namely cone dystrophy (COD) and cone-rod dystrophy (C...

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Literature Corpus work: 6f3e6a3b-05d7-5a93-b841-935005a651e2
DOI: 10.1101/2024.03.07.583919

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