Article
A single mutation in the prM protein of Zika virus contributes to fetal microcephaly.
Science (New York, N.Y.) - 17 Nov 2017
Yuan Ling, Huang Xing-Yao, Liu Zhong-Yu, Zhang Feng, Zhu Xing-Liang, Yu Jiu-Yang, Ji Xue, Xu Yan-Peng, Li Guanghui, Li Cui, Wang Hong-Jiang, Deng Yong-Qiang, Wu Menghua, Cheng Meng-Li, Ye Qing, Xie Dong-Yang, Li Xiao-Feng, Wang Xiangxi, Shi Weifeng, Hu Baoyang, Shi Pei-Yong, Xu Zhiheng, Qin Cheng-Feng
Abstract excerpt
Zika virus (ZIKV) has evolved into a global health threat because of its unexpected causal link to microcephaly. Phylogenetic analysis reveals that contemporary epidemic strains have accumulated multiple substitutions from their Asian ancestor. Here we show that a single serine-to-asparagine substitution [Ser139→Asn139 (S139N)] in the viral polyprotein substantially increased ZIKV infectivity in both human and...
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