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Article

A Reverse Mutation E143K within the PrM Protein of Zika Virus Asian Lineage Natal RGN Strain Increases Infectivity and Cytopathicity.

Viruses - 20 Jul 2022

Lin Chen-Sheng, Li Wei-Jing, Liao Chih-Yi, Kan Ju-Ying, Kung Szu-Hao, Huang Su-Hua, Lai Hsueh-Chou, Lin Cheng-Wen

Abstract excerpt

Zika virus (ZIKV) is a positive-sense single-stranded RNA virus in the Flaviviridae, which is classified into two different lineages Asian and African. The outbreak of ZIKV Asian lineage isolates in 2015-2016 is associated with the increase in cases with prenatal microcephaly and Guillain-Barré syndrome, and has sparked attention throughout the world. Genome sequence alignment and the analysis of Asian and...

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PMID: 35891552
DOI: 10.3390/v14071572
PMCID: PMC9317194

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