Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Integrated proximal proteomics reveals IRS2 as a determinant of cell survival in ALK-driven neuroblastoma

20 Nov 2018

Abstract excerpt

Oncogenic anaplastic lymphoma kinase (ALK) is one of the few druggable targets in neuroblastoma, and therapy resistance to ALK-targeting tyrosine kinase inhibitors (TKIs) comprises an inevitable clinical challenge. Therefore, a better understanding of the oncogenic signaling network rewiring driven by ALK is necessary to improve and guide future therapies. Here, we performed quantitative mass spectrometry-based...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer, Hypoxia, and Metabolism
Share to Neuroblastoma Research and Treatments
Share to Ubiquitin and proteasome pathways

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30459283
DOI: 10.1126/scisignal.aap9752

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Integrated proximal proteomics reveals IRS2 as a determinant of cell survival in ALK-driven neuroblastomaPMID 30459283Read ↗

Phosphoproteomics reveals ALK promote cell progress via RAS/JNK pathway in neuroblastomaSemantic proximity Read ↗

Quantitative Phosphoproteomic Analysis Identifies Activation of the RET and IGF-1R/IR Signaling Pathways in NeuroblastomaSemantic proximity Read ↗

Phosphoproteome and gene expression profiling of ALK inhibition in neuroblastoma cell lines reveals conserved oncogenic pathwaysSemantic proximity Read ↗

Mapping the Phospho-dependent ALK Interactome to Identify Novel Components in ALK SignalingSemantic proximity Read ↗

Global phosphotyrosine survey in triple-negative breast cancer reveals activation of multiple tyrosine kinase signaling pathways.Semantic proximity Read ↗

Quantitative phosphoproteomic analysis of the PI3K-regulated signaling network.Semantic proximity Read ↗

Comprehensive proteome, phosphoproteome and kinome characterization of luminal A breast cancerSemantic proximity Read ↗

Quantitative phosphoproteomic profiling of human non-small cell lung cancer tumors.Semantic proximity Read ↗

Tyrosine phosphoproteome profiling identifies cell-intrinsic signals limiting the efficacy of tyrosine kinase inhibitor therapiesSemantic proximity Read ↗

Alterations in the Global Proteome and Phosphoproteome in Third Generation EGFR TKI Resistance Reveal Drug Targets to Circumvent ResistanceSemantic proximity Read ↗

Phosphoproteomics of extracellular vesicles integrated with multiomics analysis reveals novel kinase networks for lung cancerSemantic proximity Read ↗

Using tandem mass spectrometry in targeted mode to identify activators of class IA PI3K in cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.