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Article

Inhibition of ALK Signaling for Cancer Therapy

9 Sept 2009

Abstract excerpt

Paradigm shifting advances in cancer can occur after discovering the key oncogenic drivers of the malignant process, understanding their detailed molecular mechanisms, and exploiting this transdisciplinary knowledge therapeutically. A variety of human malignancies have anaplastic lymphoma kinase (ALK) translocations, amplifications, or oncogenic mutations, including anaplastic large cell lymphoma, inflammatory...

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PMID: 19737948
DOI: 10.1158/1078-0432.ccr-08-2762

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