Article
Loss of glucocorticoid rhythm induces an osteoporotic phenotype in female mice.
Aging cell - 1 Oct 2021
Schilperoort Maaike, Kroon Jan, Kooijman Sander, Smit Annelies E, Gentenaar Max, Mletzko Kathrin, Schmidt Felix N, van Ruijven Leo, Busse Björn, Pereira Alberto M, Appelman-Dijkstra Natasha M, Bravenboer Nathalie, Rensen Patrick C N, Meijer Onno C, Winter Elizabeth M
Abstract excerpt
Glucocorticoid (GC)-induced osteoporosis is a widespread health problem that is accompanied with increased fracture risk. Detrimental effects of anti-inflammatory GC therapy on bone have been ascribed to the excess in GC exposure, but it is unknown whether there is also a role for disruption of the endogenous GC rhythm that is inherent to GC therapy. To investigate this, we implanted female C57Bl/6J mice with...
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