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Mice deficient in 11beta-hydroxysteroid dehydrogenase type 1 lack bone marrow adipocytes, but maintain normal bone formation.

Endocrinology - 1 Apr 2004

Justesen Jeannette, Mosekilde Lis, Holmes Megan, Stenderup Karin, Gasser Jürg, Mullins John J, Seckl Jonathan R, Kassem Moustapha

Abstract excerpt

Glucocorticoids (GCs) exert potent, but poorly characterized, effects on the skeleton. The cellular activity of GCs is regulated at a prereceptor level by 11beta-hydroxysteroid dehydrogenases (11betaHSDs). The type 1 isoform, which predominates in bone, functions as a reductase in intact cells an...

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PMID: 14715714
DOI: 10.1210/en.2003-1427

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-14715714-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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