Article
A protein network map of head and neck cancer reveals PIK3CA mutant drug sensitivity.
Science (New York, N.Y.) - 1 Oct 2021
Swaney Danielle L, Ramms Dana J, Wang Zhiyong, Park Jisoo, Goto Yusuke, Soucheray Margaret, Bhola Neil, Kim Kyumin, Zheng Fan, Zeng Yan, McGregor Michael, Herrington Kari A, O'Keefe Rachel, Jin Nan, VanLandingham Nathan K, Foussard Helene, Von Dollen John, Bouhaddou Mehdi, Jimenez-Morales David, Obernier Kirsten, Kreisberg Jason F, Kim Minkyu, Johnson Daniel E, Jura Natalia, Grandis Jennifer R, Gutkind J Silvio, Ideker Trey, Krogan Nevan J
Abstract excerpt
We outline a framework for elucidating tumor genetic complexity through multidimensional protein-protein interaction maps and apply it to enhancing our understanding of head and neck squamous cell carcinoma. This network uncovers 771 interactions from cancer and noncancerous cell states, including WT and mutant protein isoforms. Prioritization of cancer-enriched interactions reveals a previously unidentified...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.