Article

Astrocyte and mitochondrial footprints in brain-derived extracellular vesicles predict tau pathology

2025-01-13

Abstract excerpt

Tauopathies are neurodegenerative disorders characterized by abnormal tau aggregation, with primary 3R (e.g., Picks disease, PiD) and 4R (e.g., progressive supranuclear palsy, PSP) variants posing a significant diagnostic challenge. Here, we examined brain-derived extracellular vesicles (BD-EVs) isolated from the prefrontal cortex of PiD (3R), PSP (4R), and non-demented controls (CTRL) to determine if these vesicl...

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Literature Corpus work: c0826696-d099-575b-a669-7c6af4b58154
DOI: 10.1101/2025.01.09.632249

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