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Article

Ciprofloxacin accelerates aortic enlargement and promotes dissection and rupture in Marfan mice.

The Journal of thoracic and cardiovascular surgery - 1 Mar 2022

LeMaire Scott A, Zhang Lin, Zhang Nicholas S, Luo Wei, Barrish James P, Zhang Qianzi, Coselli Joseph S, Shen Ying H

Abstract excerpt

OBJECTIVE: Aortic aneurysm and dissection are major life-threatening complications of Marfan syndrome. Avoiding factors that promote aortic damage is critical in managing the care of these patients. Findings from clinical and animal studies raise concerns regarding fluoroquinolone use in patients at risk for aortic aneurysm and dissection. Therefore, we examined the effects of ciprofloxacin on aortic aneurysm and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 34586071
DOI: 10.1016/j.jtcvs.2020.09.069

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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