Article

17 β-estradiol impedes aortic root dilation and rupture in male Marfan mice

2023-05-12

Abstract excerpt

Marfan syndrome causes a hereditary form of thoracic aortic aneurysms with dilation of the aortic root. Human and animal models suggest a worse phenotype for males compared to females with respect to aneurysm size and risk of dissection. In this study we examine the effects of 17 β-estradiol on aortic dilation and rupture in a Marfan mouse model. Marfan male mice were administered 17 β-estradiol and the growth in...

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Literature Corpus work: c60efbde-8004-5c83-824d-fc0240810271
DOI: 10.1101/2023.05.09.540071

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