Article
Resveratrol Inhibits Aortic Root Dilatation in the Fbn1C1039G/+ Marfan Mouse Model.
Arteriosclerosis, thrombosis, and vascular biology - 1 Aug 2016
Hibender Stijntje, Franken Romy, van Roomen Cindy, Ter Braake Anique, van der Made Ingeborg, Schermer Edith E, Gunst Quinn, van den Hoff Maurice J, Lutgens Esther, Pinto Yigal M, Groenink Maarten, Zwinderman Aeilko H, Mulder Barbara J M, de Vries Carlie J M, de Waard Vivian
Abstract excerpt
OBJECTIVE: Marfan syndrome (MFS) is a connective tissue disorder caused by mutations in the fibrillin-1 gene. Patients with MFS are at risk of aortic aneurysm formation and dissection. Usually, blood pressure-lowering drugs are used to reduce aortic events; however, this is not sufficient for most patients. In the aorta of smooth muscle cell-specific sirtuin-1-deficient mice, spontaneous aneurysm formation and...
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