Article
Enhanced caspase activity contributes to aortic wall remodeling and early aneurysm development in a murine model of Marfan syndrome.
Arteriosclerosis, thrombosis, and vascular biology - 1 Jan 2015
Emrich Fabian C, Okamura Homare, Dalal Alex R, Penov Kiril, Merk Denis R, Raaz Uwe, Hennigs Jan K, Chin Jocelyn T, Miller Miquell O, Pedroza Albert J, Craig Juliana K, Koyano Tiffany K, Blankenberg Francis G, Connolly Andrew J, Mohr Friedrich W, Alvira Cristina M, Rabinovitch Marlene, Fischbein Michael P
Abstract excerpt
OBJECTIVE: Rupture and dissection of aortic root aneurysms remain the leading causes of death in patients with the Marfan syndrome, a hereditary connective tissue disorder that affects 1 in 5000 individuals worldwide. In the present study, we use a Marfan mouse model (Fbn1(C1039G/+)) to investigate the biological importance of apoptosis during aneurysm development in Marfan syndrome. APPROACH AND RESULTS: Using...
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