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Article

Viral recombination systems limit CRISPR-Cas targeting through the generation of escape mutations.

Cell host & microbe - 13 Oct 2021

Hossain Amer A, McGinn Jon, Meeske Alexander J, Modell Joshua W, Marraffini Luciano A

Abstract excerpt

CRISPR-Cas systems provide immunity to bacteria by programing Cas nucleases with RNA guides that recognize and cleave infecting viral genomes. Bacteria and their viruses each encode recombination systems that could repair the cleaved viral DNA. However, it is unknown whether and how these systems can affect CRISPR immunity. Bacteriophage λ uses the Red system (gam-exo-bet) to promote recombination between related...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34582782
DOI: 10.1016/j.chom.2021.09.001
PMCID: PMC8516739

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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