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Article

PEG10 amplification at 7q21.3 potentiates large-cell transformation in cutaneous T-cell lymphoma

28 Sept 2021

Abstract excerpt

Mycosis fungoides (MF), the most common form of cutaneous T-cell lymphoma, undergo large-cell transformation (LCT) in the late stage, manifesting aggressive behavior, resistance to treatments, and poor prognosis, but the mechanisms involved remain unclear. To identify the molecular driver of LCT, we collected tumor samples from 133 MF patients and performed whole-transcriptome sequencing on 49 advanced-stage MF...

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PMID: 34582557
DOI: 10.1182/blood.2021012091

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