Genomic profiling of mycosis fungoides identifies patients at high risk of disease progression.

doi:10.1182/bloodadvances.2023012125

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Article

Genomic profiling of mycosis fungoides identifies patients at high risk of disease progression.

Blood advances - 25 Jun 2024

Fléchon Léa, Arib Inès, Dutta Ankit K, Hasan Bou Issa Lama, Sklavenitis-Pistofidis Romanos, Tilmont Rémi, Stewart Chip, Dubois Romain, Poulain Stéphanie, Copin Marie-Christine, Javed Sahir, Nudel Morgane, Cavalieri Doriane, Escure Guillaume, Gower Nicolas, Chauvet Paul, Gazeau Nicolas, Saade Cynthia, Thiam Marietou Binta, Ouelkite-Oumouchal Aïcha, Gaggero Silvia, Cailliau Émeline, Faiz Sarah, Carpentier Olivier, Duployez Nicolas, Idziorek Thierry, Mortier Laurent, Figeac Martin, Preudhomme Claude, Quesnel Bruno, Mitra Suman, Morschhauser Franck, Getz Gad, Ghobrial Irene M, Manier Salomon

Abstract excerpt

ABSTRACT: Mycosis fungoides (MF) is the most prevalent primary cutaneous T-cell lymphoma, with an indolent or aggressive course and poor survival. The pathogenesis of MF remains unclear, and prognostic factors in the early stages are not well established. Here, we characterized the most recurrent genomic alterations using whole-exome sequencing of 67 samples from 48 patients from Lille University Hospital...

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PMID: 38513135
DOI: 10.1182/bloodadvances.2023012125
PMCID: PMC11222946

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