Single-cell RNA sequencing reveals markers of disease progression in primary cutaneous T-cell lymphoma.

doi:10.1186/s12943-021-01419-2

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Article

Single-cell RNA sequencing reveals markers of disease progression in primary cutaneous T-cell lymphoma.

Molecular cancer - 28 Sept 2021

Rindler Katharina, Jonak Constanze, Alkon Natalia, Thaler Felix M, Kurz Harald, Shaw Lisa E, Stingl Georg, Weninger Wolfgang, Halbritter Florian, Bauer Wolfgang M, Farlik Matthias, Brunner Patrick M

Abstract excerpt

BACKGROUND: In early-stage mycosis fungoides (MF), the most common primary cutaneous T-cell lymphoma, limited skin involvement with patches and plaques is associated with a favorable prognosis. Nevertheless, approximately 20-30% of cases progress to tumors or erythroderma, resulting in poor outcome. At present, factors contributing to this switch from indolent to aggressive disease are only insufficiently...

Topics

Adult
Aged
Biomarkers
Biopsy
Computational Biology
Disease Progression
Female
Gene Expression Regulation, Neoplastic
Humans
Immunohistochemistry

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lymphoma, T-Cell, Cutaneous

Male

Middle Aged

Mycosis Fungoides

Phenotype

RNA-Seq

Sequence Analysis, RNA

Single-Cell Analysis

Source

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Identifiers

PMID: 34583709
DOI: 10.1186/s12943-021-01419-2
PMCID: PMC8477535

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