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Risk-Reducing Bilateral Salpingo-Oophorectomy for Ovarian Cancer: A Review and Clinical Guide for Hereditary Predisposition Genes.

JCO oncology practice - 1 Mar 2022

Liu Ying L, Breen Kelsey, Catchings Amanda, Ranganathan Megha, Latham Alicia, Goldfrank Deborah J, Grisham Rachel N, Long Roche Kara, Frey Melissa K, Chi Dennis S, Abu-Rustum Nadeem, Aghajanian Carol, Offit Kenneth, Stadler Zsofia K

Abstract excerpt

Pathogenic germline variants underlie up to 20% of ovarian cancer (OC) and are associated with varying degrees of risk for OC. For mutations in high-penetrance genes such as BRCA1/2, the role of risk-reducing bilateral salpingo-oophorectomy (RRSO) in cancer prevention is well-established and improves mortality. However, in moderate-penetrance genes where the degree of risk for OC is less precisely defined, the...

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Identifiers

PMID: 34582274
DOI: 10.1200/OP.21.00382
PMCID: PMC8932494

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