Article
Society of Gynecologic Oncology statement on risk assessment for inherited gynecologic cancer predispositions.
Gynecologic oncology - 1 Jan 2015
Lancaster Johnathan M, Powell C Bethan, Chen Lee-May, Richardson Debra L
Abstract excerpt
Women with germline mutations in the cancer susceptibility genes, BRCA1 or BRCA2, associated with Hereditary Breast & Ovarian Cancer syndrome, have up to an 85% lifetime risk of breast cancer and up to a 46% lifetime risk of ovarian, tubal, and peritoneal cancers. Similarly, women with mutations in the DNA mismatch repair genes, MLH1, MSH2, MSH6, or PMS2, associated with the Lynch/Hereditary Non-Polyposis...
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